Endogenous Laser Induced Ventricular Enhancement: a novel approach for Heart Failure

28 October 2014

The therapy, called Endogenous Laser Induced Ventricular Enhancement (ELIVE), was developed by researchers from the Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, USA, and the Department of Cardiovascular Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany.

Endogenous Laser Induced Ventricular Enhancement: a novel approach for Heart FailureA recent article published in the Journal of Stem Cell Research reports the potential for a new treatment for Heart Failure based on low energy laser treatment. The therapy, called Endogenous Laser Induced Ventricular Enhancement (ELIVE), was developed by researchers from the Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, USA, and the Department of Cardiovascular Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany.

 

This therapeutic approach has evolved from the results achieved in a clinical trial conduced in Germany, that assessed safety and feasibility of laser-supported CD133pos intramyocardial cell transplantation in patients suffering from ischemic cardiomyopathy.”This study demonstrated significant restoration potential of hibernating myocardium upon autologous, bone marrow-derived cell transplantation when supported by low-energy laser treatment”,  said the lead scientist Dr. Michel Klein, cardiac surgeon. ELIVE therapy now employs a new generation of laser, featuring a hollow fiber waveguide, rendering this approach amenable for a minimally invasive procedure, in combination with a preceding granulocyte colony stimulating factor (GCSF) treatment of the patient in order to mobilize endogenous stem and progenitor cells. The rationale of this new therapy is for the patient himself to become his own ‘bioreactor’, effectively triggering and amplifying endogenous regeneration mechanisms based on autologous stem and progenitor cells.

 

REFERENCE: Heke and Klein, J Stem Cell Res Ther 2014, 4:9.

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